Chloroquine effect on lysosomes

Discussion in 'Without A Doctor Prescription' started by Top100, 19-Mar-2020.

  1. vadovsky Well-Known Member

    Chloroquine effect on lysosomes


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In this study, ARPE-19 cells were treated with chloroquine to inhibit lysosomal function. Chloroquine-treated ARPE-19 cells demonstrate a marked increase in vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes and lipid bodies with LAMP-2 and LipidTOX co-localization, respectively. Chloroquine is a useful antimalarial and anti-inflammatory drug. It affects the lysosomes of malarial parasites 15, those of leukocytes and pancreatic exocrine cells 6, 7, and those of liver cells in the rat 4. In these examples the lysosomes are altered in structure, leading to the formation of myeloid bodies.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine effect on lysosomes

    Chloroquine for research Cell-culture tested InvivoGen, Chloroquine treatment of ARPE-19 cells leads to lysosome.

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  6. Chloroquine CQ is a lysosomotropic agent with an extensive range of biological effects 1. Historically known for its anti-malarial activity, chloroquine is a widely used biological research tool for studying autophagy inhibition. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH.

    • CST - Chloroquine.
    • The effect of chloroquine on rat heart lysosomes..
    • Chloroquine - American Osteopathic College of Dermatology AOCD.

    Chloroquine has been used as an anti-malarial drug and is known as a lysosomotropic amine as well. The effects of chloroquine on lysosomal integrity in cultured rat hepatocytes were studied by. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

     
  7. admaus User

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine MotherToBaby Is it safe to take plaquenil hydroxychloroquine while pregnant? Hydroxychloroquine 'Probably Safe' in Pregnancy MDedge ObGyn
     
  8. aglamrug New Member

    Treatment of Systemic Lupus Erythematosus An Update - American Family. Systemic lupus erythematosus is a disease that continues to evolve over time. Thus, a patient who presents with skin and joint disease remains at risk for renal disease even after having lupus.

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