I read that the sulfa in Plaquenil is different from those in antibiotics and most people with Lupus have an allergy to Sulfa but can take Plaquenil without any problems. I can say, however, that I have not had any cross allergic reaction to other drugs sometimes associated with sulfa allergies. Whether you try Plaquenil or not is ultimately up to you and your doctor, but a lot will depend on the type and severity of reactions that you've had. Does going off plaquenil cause fever after surgery Chloroquine transfection protocol Hydroxychloroquine sulfate Plaquenil is not a sulfa drug. That is a misconception. However, hydroxychloroquine can be associated with serious dermatological side effects including severe rashes. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects. I can't take sulfa drugs so I haven't researched Azulfidene as much as the others, but it seems to be somewhat less commonly used in this community than Plaquenil and Methotrexate. I was started on Plaquenil two months ago and have had zero side effects beyond the very first dose. My reaction to sulfa consisted of wheezing, but no major distress, and Plaquenil was sufficiently different from Gantrisin that my doctor felt comfortable with prescribing it. Rashes are certainly a lot less severe than respiratory reactions. Plaquenil sulfa drug Is hydroxychloroquine Sulfate a member of the sulfa drug family?, Plaquenil Hydroxychloroquine Sulfate - Sanofi Plaquenil and hair colorPlaquenil cure headaches Mar 17, 2019 Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hydroxychloroquine Uses, Dosage & Side Effects -. Methotrexate, Plaquenil or Sulfasalazine Azulfidine.. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Does Plaquenil Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in. Feb 17, 2009 Plaquenil isn't a 'sulfa' drug which means a certain sort of antibiotic, the sulfonamides. Plenty of people who are allergic to those sulfa drugs take Plaquenil without any problem. This sounds all very odd to me!