So whenever something goes wrong inside, it eventually starts reflecting on the skin. One such sign is hyperpigmentation, a sign from your skin that all is not well within your body. What is the best time of day to take hydroxychloroquine Can you od on plaquenil Plaquenil for dermatomyositis Health conditions that can cause hyperpigmentation Skin discolouration or hyperpigmentation is a sign of underlying health problems. Switch to हिंदी. Dec 15, 2017 It is mainly caused due to the overproduction of melanin, the pigment that gives skin its colour. Although it is usually associated with ageing, hyperpigmentation may usually point towards an underlying health condition. Here are some of the health problems that could cause hyperpigmentation. Aug 18, 2011 Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. It is mainly caused due to the overproduction of melanin, the pigment that gives skin its colour. Hyperpigmentation is a dermatological condition when the getting discoloured and darkened in places. Plaquenil cause hyperpigmentation Plaquenil Side Effects Common, Severe, Long Term -, Health conditions that can cause hyperpigmentation. Plaquenil rheumatoid arthritis remissionChloroquine pretreatment before transfection One of the potential long-term side-effects of using anti-malarial medications such as hydroxychloroquine Plaquenil, chloroquine, and quinacrine is the development of dark-colored patches on the skin. They often appear brown, black, or black and blue and tend to develop on the legs, especially around the shins. Hydroxychloroquine and skin darkening Hi All. - LUPUS UK. Skin Discoloration and Plaquenil - Arthritis Information. Hydroxychloroquine-Induced Pigmentation in Patients With.. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. PLAQUENIL has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with or without antidiabetic medications see DRUG INTERACTIONS and ADVERSE REACTIONS. Patients treated with PLAQUENIL should be warned about the risk of hypoglycemia and the associated clinical signs and. I think it's due to Hydroxycholoroquine-induced hyperpigmentation an example of drug-induced skin pigmentation. I thought it worth showing those of you on the medication. Why is it so much worse on the right forearm? Well she's only just started to drive again.