Additionally, another exception occurred while executing the custom error page for the first exception. Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Chloroquine cells Hydroxychloroquine and ccca alopecia Teaching about hydroxychloroquine A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. It is available in 200 mg tablets of hydroxychloroquine phosphate each containing 155 mg of hydroxychloroquine. 1 Although commonly used in the treatment of rheumatologic diseases, it is a rare source of overdose in the United States. However, life-threatening symptoms can occur within an hour of ingestion. Hydroxychloroquine HCQ Background Hydroxychloroquinesulfate •Chloroquine CQ first synthesized in 1930s by Hans Andersag •Alternative to quinine found in Peruvian tree bark •Original use combat malaria in WWII •Less toxic form, hydroxychloroquine HCQ developed later •Started being used in 1950’s, toxicity first noted 1963 Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Photopsia plaquenil toxicity Plaquenil Side Effects Common, Severe, Long Term -, Treatment of hydroxychloroquine overdose - ScienceDirect Visual defects hydroxychloroquineIs plaquenil a nsaidsCan i get plaquenil in australiaPlaquenil and headachesPlaquenil for recurrent pregnancy loss It is a derivative chloroquine, also an antimalarial agent which has a much higher risk of toxicity. Plaquenil can rarely cause a retinal problem involving the central visual area, or macula. Retinal toxicity from Plaquenil is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Medications that can Affect the Eye or Visual System. COPE Disclosures Plaquenil Toxicity Update. Free Calculator Aids in Plaquenil Dosing. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so. Photopsia perception of flashes or flickering light, metamorphopsia distortion e.g. of straight lines and, in its later stages, reduced colour vision and peripheral field loss are also reported. Early. review of mfERG ring ratios in Plaquenil toxicity. Doc Ophthalmol. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1.