Additionally, another exception occurred while executing the custom error page for the first exception. Ototoxicity is, quite simply, ear poisoning (oto = ear, toxicity = poisoning), which results from exposure to drugs or chemicals that damage the inner ear or the vestibulo-cochlear nerve (the nerve sending balance and hearing information from the inner ear to the brain). Hydroxychloroquine and sun Seronegative rheumatoid arthritis and plaquenil Hair loss lupus plaquenil Vestibular ototoxicity or vestibulotoxicity are terms used to describe ototoxicity that affects the balance organs or the vestibular branch of the vestibulo-cochlear nerve. It is important to note that no drug is known to cause Ménière’s disease, benign paroxysmal positional vertigo, or any other vestibular disorder causing fluctuating. Chloroquine should be used with caution in patients with neurological disease including preexisting hearing impairment or seizure disorder. Polyneuritis, ototoxicity, seizures, neuromyopathy, and acute extrapyramidal symptoms dystonia, dyskinesia, tongue protrusion, torticollis have occurred with chloroquine therapy. Most important agents to cause irreversible ototoxicity are Aminoglycosides and Cisplatin. FACTORS INFLUENCING OTOTOXOCITY Drug concentration in inner ear Dose, Absorption, Clearance from body, Selectivity to ear Intolerance Renal and hepatic disease Placental transport Chloroquine, Streptomycin can lead to ototoxicity in fetus Genetic. The parts of the brain that receive hearing and balance information from the inner ear can also be affected by poison, but this is not technically considered ototoxicity and won’t be covered in this information sheet. Because the inner ear is involved in both hearing and balance, ototoxicity can result in disturbances of either or both of these senses. Chloroquine ototoxicity Ototoxic Drugs Drugs That Cause Tinnitus Tinnitus Talk., Chloroquine Phosphate chloroquine phosphate dose. Plaquenil diagnosisPlaquenil sleeplessnessPlaquenil baseline eye exam duration Ototoxicity is typically associated with bilateral high-frequency sensorineural hearing loss and tinnitus. Hearing loss can be temporary but is usually irreversible with most agents. Generally, antibiotic-induced ototoxicity is bilaterally symmetrical, but it can be asymmetrical. Ototoxicity Overview, Aminoglycosides, Other Antibiotics. Ototoxicity. Ototoxicity of Chloroquine JAMA Otolaryngology–Head & Neck.. Ototoxicity can affect anyone receiving treatment from the medications listed above. However, the likelihood of developing ototoxicity is highly dependant on which drug is being administered, duration of use, and several other underlying factors, such as kidney function and the use of other ototoxic drugs at the same time. The present study provides the first evidence for the occurrence of autophagy and its role in cisplatin-induced ototoxicity. In conclusion, autophagy plays a pro-death role in cisplatin-induced ototoxicity via mTOR pathway, and modulating the autophagic pathway might be another strategy against cisplatin-induced ototoxicity. Certain painkillers and fever reducers salicylates, quinine, chloroquine; Ototoxic medications can affect everybody regardless of factors like age or gender. Fortunately, not everybody who takes one of these drugs will experience ototoxic side effects.