The same generic drug, made by a different manufacturer, can indeed look different. A: Yes, it is confusing, and unfortunately, it's fairly common. How does chloroquine work against malaria Can plaquenil cause eye problems Benadryl diphenhydramine and Vistaril hydroxyzine pamoate are antihistamines used to treat allergic skin reactions such as hives or contact dermatitis. Benadryl is also used to treat insomnia, motion sickness, and mild cases of Parkinsonism. Vistaril is also used as a sedative to treat anxiety and tension, or to control nausea and vomiting. The 'Hydroxyzine High' and Abuse. Additionally, hydroxyzine can enhance the effects of opioid drugs, including morphine, oxycodone, and heroin. Vistaril is non-habit forming, but people may seek out the drug specifically to abuse it and get a feeling of being "high" The study is based on hydroxychloroquine sulfate and hydroxyzine hydrochloride the active ingredients of Plaquenil and Hydroxyzine, respectively, and Plaquenil and Hydroxyzine the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Dosage of drugs is not considered in the study. Then, because pharmacies often change suppliersor their wholesalers doa pharmacy's own stock of a particular generic drug may continually rotate. Additionally, generic drug manufacturers can also take it a step further by producing generic pills that look different from another manufacturer's generics pills. Are hydroxyzine and plaquenil the same thing Benadryl vs Hydroxyzine Comparison -, What are the side effects of hydroxyzine? AnswersDrive Hydroxychloroquine blind By researching, I found information that hydroxyzine pamoate the capsule form crosses the blood/brain barrier, whereas hydroxyzine hydrochloride the tablet form does not. That could help to explain why one might cause someone to be susceptible to having seizures while the other one does not. Hydroxyzine pamoate vs hydroxyzine hcl? -. Plaquenil and Hydroxyzine drug interactions - eHealthMe. Compare Hydroxyzine vs Meclizine - Comprehensive Analysis by.. Re Plaquenil - when to take the 2 doses? I kinda was thinking the same thing, but then wondered why it is prescribed as "one pill twice a day" instead of "two pills once a day". I see that you have hashimoto's & connective tissue disease. At my last hospital, the docs could order Atarax hcl or Vistaril pamoate and they were getting hcl, no matter what. Hcl was the only formulation we carried. Where I work now, if a doc goes to order hydroxyzine, the order reads like This hydroxyzine Atarax/Vistaril and the pt would get the pamoate because that's what we stock. Yes, both formulations have the same active ingredient hydroxyzine, BUT they are attached to 2 DIFFERENT salt forms Hcl which is found in the tablet form, and under the brand name "Atarax" vs. pamoate which is found in the capsule form, and under the brand name "Vistaril". The pamoate formulation is more lipophilic.