Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine amebiasis Hydroxychloroquine blindness Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. But have been on Medrol, Plaquenil, and only a short time of Cellcept. My ANA went neg. But since they weaned me from 10 mg Medrol to 8- then had the eye problems, chills, diarrhea, etc, then to 6 mg, again with chills, eye problems, etc, the ANA went to 40 then 80 which I know is very low compared to before, but why does it do this? But Plaquenil could help someone ANA-negative for a few reasons that I've read about. First, maybe you do have positive ANA & positive autoantibodies, but all your bloodwork was done when those levels had fallen. Then there's that rare kind of SLE called Ro-lupus. Also, in the discoid lupus "subset", people remain ANA-negative. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Taking plaquenil with negative ana Plaquenil? Yes or No? - Lupus - Inspire, Do steroids and Plaquenil change the ANA results? Lupus. Difference between hydroxychloroquineGetting a cold while on plaquenilHydroxychloroquine 200 mg para que se usaHydroxychloroquine sulfate for skinWhat type of arthritis is plaquenil prescribed for An antinuclear antibody test looks for autoimmune diseases such as lupus or rheumatoid arthritis. The ANA blood test is just one part of a doctor’s autoimmune disease diagnosis, along with a. Antinuclear Antibodies ANA Test - WebMD. Negative ANA Lupus? - Healthboards. Hydroxychloroquine Side Effects, Dosage, Uses, and More. I know this is an old post but Jennifer I had a question. I have been taking plaquenil for 7 years. I take 200mg per day. I have sjogrens and cutaneous lupus. MY ANA is homogeneous,SSA 4.6, SSB normal ESR 31. All other lab negative. Recently I had shingles and was given prednisone which then caused an outbreak of HP. Oct 29, 2009 At least it's something I'm going to continue to pursue. Maybe my ANA went negative because of the Plaquenil.with the other changes, I'm inclined to believe it had quite a lot, if not everything to do with the dietary changes. There was one negative to all the improved bloodwork, and that is that my CRP actually increased doubled, really. Q5. My mother just passed away with Lupus and my uncle and my cousin also have lupus. I just had my first ANA that was speckled. My other previous ones had all been negative. I already have the ankles that swell constantly, the joint pain, the low blood counts, low D, low B12, and I’m throwing protein into the urine.