Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. How much is plaquenil without insurance Hydroxychloroquine pharmacokinetics Can plaquenil cause seizures Hydroxychloroquine retinopathy. It is known that some people who take. hydroxychloroquine for more than five years and/or in high doses are at increased risk of. damage to their retina, the light sensitive layer of cells at the back of the eye. This is known as. retinal toxicity or retinopathy. I started taking Plaquenil 2/2009 by 8/2009 I was noticing changes in my vision. Thing were going dim but the eye doctor kept telling me there was no toxicity. By 2/2010 things were so dim I could not see to shop in stores. I quit taking Plaquenil but the DR still said no toxicity. My eyes continued to get worst. The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil toxicity macula Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS, Has anyone experienced plaquenil toxicity with damage to eyes? Chloroquine phosphate and pregnancyHydroxychloroquine and ocular toxicity recommendations on screening 2009 SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Plaquenil Risk Calculators. Hydroxychloroquine toxicity - EyeWiki. Management when they are seeing patients who are on or about to begin Plaquenil. Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes. Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Focus on Eyes Long-term Plaquenil intake can affect your vision. Taking high doses or long-term treatment of Plaquenil, an anti-malaria drug used to treat lupus, can lead to vision problems.