It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Chloroquine and g6pd Plaquenil lowers blood sugar Can you drink alcohol with hydroxychloroquine This condition does not cause symptoms and is reversible with cessation of the medication. The finding of corneal verticillata bares no correlation with retinal toxicity and is not an indication to stop the medication 1. The hallmark of hydroxychloroquine toxicity is bilateral pigmentary retinopathy 1. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. We present a case of a 67-year-old female who presented with a twelve-month history of progressive blurred vision in both eyes. The patient was on hydroxychloroquine 200 mg twice a day for eight years for the treatment of scarring alopecia. Two years prior to presenting, the patient was found to have chronic kidney disease stage 3 secondary to hypertension. Examination revealed. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Plaquenil liver kidney toxicity Rx Side Effects New Plaquenil Guidelines and More., Hydroxychloroquine Plaquenil Toxicity and Recommendations for Screening Can i take plaquenil for heart attack People weighing more than 135 lbs. will stay within the safety guidelines not more than 6.5mg/kg/day at 400mg per day but people under 135lbs. should probably only be taking 200 mg per day. Other risk factors for Hydroxychloroquine retinal toxicity include kidney or liver disease and obesity. What can Hydroxychloroquine Plaquenil do to my eyes?. A Case of Severe Hydroxychloroquine-Induced Retinal Toxicity in a.. Plaquenil side effects - kidney problems? - Symptoms - Life With Lupus. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Age, liver disease, and genetic factors e.g. polymorphisms in the cytochrome P450 gene which may impact blood concentrations are thought to be lesser risk factors associated with toxicity risk. Kidney and liver disease predispose to hydroxychloroquine toxicity due to impaired clearance of the drug. The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid.