This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Chloroquine malaria prophylaxis Chloroquine resistance countries Hydroxychloroquine for travel Primaquine and chloroquine Chloroquine inhibits the malignant phenotype of glioblastoma These tumors also are refractory to standard treatment strategies, which consist of both radio- and chemotherapy. Consequently, clinical responses are invariably transitory and the prognosis barely exceeds 14 months as local or distant or both recurrence is inevitable. Stephen, I recall discussing other studies that pointed to the effectiveness of Chloroquine in the case of EGFRvIII about 3 years ago now. Seems there is some pretty solid evidence for CQ with EGFRvIII tumors. Uses Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live. Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Chloroquine glioblastoma Chloroquine - Wikipedia, Our brain tumor cocktails and stories Chloroquine for GBM. Chloroquine resistance tanzaniaChloroquine phosphate rheumatoid arthritis Investigators at the University of Colorado are now reporting that adding the anti- malaria drug chloroquine to standard therapies may help combat resistance to therapy and also resensitize. Anti-malaria Drug Chloroquine May Help Combat Some Brain.. Chloroquine Oral Uses, Side Effects, Interactions.. The Addition of Chloroquine to Chemoradiation for Glioblastoma. Conclusion These results suggest that CQ, alone or as an adjuvant therapeutic, could be used to inhibit the GBM malignant phenotype and could benefit GBM afflicted patients. Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta SpringerLink Jul 30, 2019 Before the administration of chloroquine, the patient had only a mild skin erythema in the irradiated area, which was consistent with the radiotherapy dose she had received. On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation. Methods and analysis We describe a dose-finding phase Ib/II clinical trial, in which patients with IDH1/2-mutated chondrosarcoma, glioma and intrahepatic cholangiocarcinoma are treated with a combination of metformin and chloroquine.