Ocular safety of hydroxychloroquine

Discussion in 'Generic & Brand Canadian Pharmacy' started by n_val, 20-Mar-2020.

  1. Archikudesnik Well-Known Member

    Ocular safety of hydroxychloroquine


    Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. The mechanism of this toxicity is not clearly understood, though it is believed that the drug molecule binds to melanin in the retinal pigment epithelium (RPE).

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    Jan 18, 2019 Hydroxychloroquine Plaquenil was originally used to treat malaria and is now used mostly to treat rheumatological and dermatological diseases. Its most frequent use now is for Rheumatoid Arthritis RA and Lupus and is often very effective in mitigating the joint and arthritic symptoms these diseases can cause. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity.

    Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. This leads to disruption and damage to the photoreceptors and outer nuclear and plexiform layer, sparing the foveal center and resulting in the “bull’s eye” appearance in the late stage of the disease.

    Ocular safety of hydroxychloroquine

    Hydroxychloroquine Uses, Dosage & Side Effects -, Hydroxychloroquine-Induced Retinal Toxicity - American.

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  6. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications.

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    Jun 13, 2019 Before Plaquenil treatment begins. You will have a “baseline” eye exam. This measures the health of your eyes and looks for retinal or macular disease. Once a year while taking Plaquenil. After five years of Plaquenil treatment, when retina damage is likely to begin. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Jan 05, 2020 Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1

     
  7. spearhad Well-Known Member

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Remdesivir and chloroquine effectively inhibit the recently. Chloroquine - an overview ScienceDirect Topics Chloroquine - Wikipedia
     
  8. secorp XenForo Moderator

    Will you have Rickets with Plaquenil - eHealthMe Summary Rickets is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months, also take medication Enbrel, and have Osteoporosis.

    I'm using plaquenil hydroxychloroquine 200mg and.