Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Scholarly articles plaquenil autoimmune encep halitis Plaquenil retinopathy to reverse Plaquenil and bleeding Chloroquine failure deaths in africa Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Initial dose for the treatment of SLE, 400mg×2/day, is about the dose used in one of the studies above. Maintenance dose would keep the serum concentration constant. Assuming HCQ is effective, it would most definitely be protective in doses used in SLE patients. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine use in sle Chloroquine Oral Uses, Side Effects, Interactions., Hydroxychloroquine Plaquenil thread COVID19 Hydroxychloroquine urticaria angioedemaPlaquenil side effects menstrual Early use of hydroxychloroquine prevents damage accrual in systemic lupus erythematosus. Birmingham, AL - Starting the antimalarial drug hydroxychloroquine HCQ Plaquenil early on in the disease process may help prevent damage accrual in patients with systemic lupus erythematosus SLE 1. Hydroxychloroquine in SLE. Chloroquine C18H26ClN3 - PubChem. Discoid Lupus Erythematosus Medication Antimalarial agents.. The aminoquinolones chloroquine and hydroxychloroquine have been widely used in the treatment of SLE. These drugs can cause a reversible, visually insignificant keratopathy cornea verticillata and, more importantly, an irreversible sight-threatening maculopathy. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Chloroquine can be used to kill malaria parasites living in red blood cells but the medication may not necessarily be efficient at killing these parasites in other body tissues. Doctors often prescribe this medication as part of certain treatment plans for lupus and other immune system diseases.