It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Difference between primaquine and chloroquine Plaquenil dose for malaria prevention Chloroquine per week starting at least 1 week before. traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 300mg base 500mg salt. Taking digoxin with hydroxychloroquine may increase the levels of digoxin in your body. This may increase your risk of side effects from digoxin. Insulin and other diabetes drugs. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. Chloroquine and digoxin Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs, Hydroxychloroquine Side Effects, Dosage, Uses, and More Chloroquine maculopathy risk factors Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Chloroquine Oral Uses, Side Effects, Interactions, Pictures.. Chloroquine Indications, Side Effects, Warnings -. Digoxin, cyclosporine, and certain beta blockers may cause drug interactions with hydroxychloroquine. This eMedTV segment explores what may happen if these drugs are taken with hydroxychloroquine and lists other drugs that may cause an interaction. The combo of digoxin and propranolol is cardiotoxic, while diazepam and morphine should act as a anaestethics and analgesics, perhaps creating respiratory depression. It has been used with reported success on a large number of terminally ill patients. Interaction between digoxin and the natural cinchona alkaloid quinidine is well documented. A possible interaction between digoxin and the semisynthetic cinchona derivative hydroxychloroquine is reported in this communication. Chloroquine and hydroxychloroquine, Meyler's Side Effects of Drugs The International Encyclopedia of Adverse Drug.