Chloroquine brain cancer

Discussion in 'Chloroquine 150 Mg' started by theos, 17-Mar-2020.

  1. metrod Well-Known Member

    Chloroquine brain cancer


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    Investigators looked at vemurafenib-resistant brain tumors and found that chloroquine was highly effective. 1 It is well known that kinase inhibitors are effective cancer therapies. However, the. In addition to its p53-activating effects, chloroquine may also inhibit glioma cell growth via p53-independent mechanisms. Our results clarify the mechanistic basis underlying the antineoplastic effect of chloroquine and reveal its therapeutic potential as an adjunct to glioma chemotherapy. Aug 27, 2018 Chloroquine a convoluted path from malaria to cancer treatment Chloroquine CHQ is a well-known antimalarial that has recently attracted considerable attention for its anti-neoplastic activites. Application of CHQ for cancer treatment is an example of drug re-purposing, a strategy for identifying new therapeutic indications for drugs that have initially been developed for different medical applications 7.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Chloroquine brain cancer

    Autophagy Inhibition Improves. - Cancer Discovery, Chloroquine activates the p53 pathway and induces apoptosis.

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    Nov 15, 2015 Indeed, Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. This is why Chloroquine has become part of many clinical trials, in combination with chemotherapy and other form of cancer treatments. Chloroquine Chloroquine and Sulfadoxine – Pyrimethamine, the first line drugs in the treatment of malaria, banned by the Federal Government in 2005 because of increasing evidence of drug resistance, which had led to treatment failures, has being found to be used for treatment of cancer. Over the last decade, a dozen Phase I and I/II clinical trials have been completed and published using the autophagy inhibitors, Chloroquine CQ or hydroxychloroquine HCQ in cancer. These lysosomal targeting compounds were originally approved for use in humans as anti-malarial drugs but have been repurposed as autophagy targeting cancer therapeutics.

     
  8. nick-sphere Well-Known Member

    Methemoglobinemia (congenital or acquired) occurs when red blood cells (RBCs) contain methemoglobin at levels higher than 1%. Primaquine - FDA prescribing information, side effects and uses Methemoglobinemia Practice Essentials, Background. Methemoglobinemia Treatment, diagnosis, and types
     
  9. bloodhound Moderator

    Psychiatric side effects of medications prescribed in. Chloroquine, another antimalarial, also produces psychiatric and neurological side effects agitation, aggressiveness, amnesia, confusion, depression, hallucinations, and mania. Psychiatric changes under chloroquine may develop Insidiously. Memory or perception changes can be the only clues to side effects In this developing phase.

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