My rheumy thinks in the long run plaquenil will not be enough for me and I will have to go to the next step. My question is, if plaquenil doesn't work, what is the next step of medication? Plaquenil generic side effects Plaquenil pregnancy drug class Pill image hydroxychloroquine 200mg tablets Hydroxychloroquine se puede consumir alcohol Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first; even when your symptoms improve to help keep the disease under. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. What is Plaquenil Hydroxychloroquine? Plaquenil is most known for its original purpose treating and preventing malaria. Malaria is a disease caused by parasites that can enter the body through a mosquito bite. The essential ingredient, known as quinine, is derived from the bark of the cinchona plant. But the way my joint and skin pain has been going I may need bigger guns. Rheumy is very conservative with meds and always looks for the smallest dose possible and the least amount of meds. What if plaquenil doesn't work Tranexamic Acid Side Effects and Possible Drug Interactions, Hydroxychloroquine Side Effects, Dosage, Uses, and More Is plaquenil safe to useHow long until plaquenil side effects go away With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center. Plaquenil Hydroxychloroquine for Lupus - LupusCorner. Methotrexate not working so what next? Hi everyone as. - NRAS. Plaquenil comes in 200 mg tablets, and many doctors just off-handedly put everyone on 200 mg twice a day. It doesn’t work. However, there is a variation of the field test called SITA Fast. Plaquenil is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take Plaquenil with a meal or a glass of milk. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay. No methotrexate doesn't always mean your hair will fall out or thin but some of the side effects are scary, but before you an progress onto other meds methotrexate is mandatory. for me methotreaxte and plaquenil does't work and i' intonate of sulfa so i am started embrel which states you have to have tried 2 of 3 meds and methotrexate is 1 of them.