What is chloroquine used for in cell biology

Discussion in 'Canadian Pharmaceuticals Online' started by imya, 24-Feb-2020.

  1. houmessTres Moderator

    What is chloroquine used for in cell biology


    For decades, the drug was a front-line treatment and prophylactic for malaria. In a three-page paper published Tuesday in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture.

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    A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Chloroquine diphosphate, apoptosis and autophagy inhibitor CAS 50-63-5, with 98% purity. Water soluble compound. Join researchers using our high quality biochemicals. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver.

    “It’s interesting in that it really lacks a lot of details but, nevertheless, if you look at the data as presented, at least in vitro, it seems like chloroquine can be used as an early-stage drug,” he said. Their drug screen evaluated five other drugs that were not effective. Though the paper is brief, John Lednicky, a professor at the University of Florida’s Emerging Pathogens Institute, found its results intriguing.

    What is chloroquine used for in cell biology

    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs, Chloroquine diphosphate CAS 50-63-5 98% purity. - Abcam

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  7. Chloroquine is an inhibitor of the lysosomal degradation of the DNA which is taken up by the cells, so as leelee said, transfection should have been successful, albeit at a slightly lower level than if you would have added the chloroquine. In my normal transfections, I never add chloroquine and get high efficiencies nevertheless.

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    Chloroquine diphosphate is used as an antimalarial drug and also functions to increase sensitivity of tumor cells to radiation and chemotherapy via inducing autophagy 1. Chloroquine diphosphate has been reported as an adjuvant for radiation and chemotherapy for inducing cell autophagy to anti-cancer cells proliferation or metastasis 2. There is a strong evidence that withdrawing extensive use of chloroquine will ultimately lead to the reemergence of chloroquine-sensitive parasites. A study done in Malawi where chloroquine use was withdrawn for over 10 years showed an almost disappearance of chloroquine resistance Plasmodium falciparum strains 2. Figure. 1. Use of Chloroquine phosphate tablets for indications other than acute malaria is contraindicated in the presence of retinal or visual field changes of any etiology. Use of Chloroquine phosphate tablets is contraindicated in patients with known hypersensitivity to 4-aminoquinoline compounds. Warnings. Chloroquine-Resistant Malaria

     
  8. kentoff XenForo Moderator

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  9. RETUCEXE User

    Psoriasis Associated with Plaquenil Hydroxychloroquine - Dr. The findings were consistent with lupus of the skin. She was referred to a rheumatologist who prescribed Plaquenil. However, the rash continued to spread, became more inflamed and scaly, but seemed to improve in parts of the body exposed to sunlight.

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  10. Taptap New Member

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Cardiac disorders Cardiomyopathy which may result in cardiac failure and in some cases a fatal outcome see WARNINGS and OVERDOSAGE. PLAQUENIL prolongs the QT interval. Ventricular arrhythmias and torsade de pointes have been reported in patients taking PLAQUENIL see OVERDOSAGE and DRUG INTERACTIONS.

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