While many of these can be grouped by anatomic location or type of toxicity, there are also individual medications with characteristic effects. In this article, we will describe several major categories of pharmacologic retinal toxicity and discuss examples of individual medications. C1q nephropathy plaquenil Benign shin tumor and plaquenil Plaquenil et grossesse H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative. • Cystoid macular edema sometimes may develop, 11 and advanced cases show widespread RPE and retinal atrophy with loss of visual acuity, peripheral vision, and night vision. Mar 17, 2017 Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes. The presentation goes over how to spot and what testing to perform to make sure there is no retinal toxicity. Both medications have been shown to bind melanin and to concentrate in the iris, ciliary body and retinal pigment epithelium, altering normal physiologic function. Chloroquine (Aralen) and hydroxychloroquine (Plaquenil) are traditional antimalarial agents now used in the treatment of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Plaquenil macular edema Plaquenil - FDA prescribing information, side effects and uses, Plaquenil Toxicity Screening Macula and Retina Institute c. Plaquenil effects on liverCvs hidroxicloroquina plaquenilChloroquine lysosomal acidificationMalaria prophylaxis chloroquine dose Symptoms of Plaquenil toxicity are similar to other macular problems and may include Decreased fine vision or difficulty reading. Changes in Color vision Missing Spots or shadows near the center of the vision Plaquenil Toxicity Screening - Retina Group of New York. Plaquenil Toxicity Screening Macula and Retina Institute c/o.. Plaquenil in Los Angeles, CA Macula and Retina Institute. Risk of Toxicity The risk of toxicity is dependent on daily dose and duration of use. At recommended doses, the risk of toxicity up to 5 years is under 1% and up to 10 years is under 2%, but it rises to almost 20% after 20 years. However, even after 20 years, a patient without toxicity has only a 4% risk. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Dec 17, 2019 Depending on the cause of the macular edema and the treatment plan your doctor has recommended, the macular edema may take several months to resolve. During this time, it is important to follow the treatment regimen that your ophthalmologist recommends in order for your treatment to be effective.