Quinolone and chloroquine resistance development

Discussion in 'Canadian Online Pharmacies' started by Mokkey, 03-Mar-2020.

  1. watch# New Member

    Quinolone and chloroquine resistance development


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Quinolones and fluoroquinolones increase the sensitivity of the skin to the sun and may cause photo-sensitivity reactions and severe sunburn on exposed areas of skin. Quinolones and fluoroquinolones are not suitable for people with myasthenia gravis, certain heart rhythm disturbances. The development of ciprofloxacin resistance in E. coli was examined after serial exposure to chloroquine. Patient and laboratory isolates of E. coli resistant to ciprofloxacin were assessed by PCR-sequencing for quinolone-resistance-determining-region QRDR mutations.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Quinolone and chloroquine resistance development

    Chloroquine & Hydroxychloroquine supporting chemo., List of Common Quinolones + Uses, Types & Side Effects.

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  5. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance.

    • Chloroquine - Wikipedia.
    • Antimalarial Therapy Selection for Quinolone Resistance among..
    • Chloroquine - FDA prescribing information, side effects..

    The prolific development of the quinolones began in 1962, when Lesher et al. made the accidental discovery of nalidixic acid as a by-product of the synthesis of the antimalarial compound chloroquine. This discovery led to the development of a library of quinolone compounds, especially the newer quinolones in clinical use at the present time. Further studies of halogenated alkyl- and alkoxy-quinolones may lead to the development of safe and effective therapeutics for use in treatment or prevention of malaria and other parasitic diseases. Many of the traditional antimalarials, such as chloroquine, has been declining because of the emergence of multidrug-resistant strains of Plasmodium parasites. The widespread nature of multidrug resistance has shifted the emphasis to artemisinin combination therapies ACTs as first-line treatments in malaria-endemic countries. Whereas ACTs

     
  6. Qert User

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine - Prescription Drug Information, Interactions. Zinc With Vitamins A And C Oral Interactions with Other. HibiscusUses, Side Effects, Dosage, Interactions & Health.
     
  7. NEP2N New Member

    Crystal structure - Wikipedia In crystallography, crystal structure is a description of the ordered arrangement of atoms, ions or molecules in a crystalline material. Ordered structures occur from the intrinsic nature of the constituent particles to form symmetric patterns that repeat along the principal directions of three-dimensional space in matter.

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