Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Ic hydroxychloroquine Plaquenil fish oil Hydroxychloroquine sulphate Overall Plaquenil did take away the muscle and joint pain. It worked wonders for that. For that reason I am satisfied with plaquenil for what I took it for. Took about 5-6 months to see full effect. Since reducing the dose from 400mg to 200mg 4 months ago I do feel some of this pain returning You win some, you lose some! M 49 I am glad I switched to the cymbalta, perhaps the combination of it and 400 mg of plaquenil will work for me. It seemed to help the swelling in my hands too. I had an uncle with RA whose been dead for years now but it was before all the better drugs came out and he was so crippled up. It was so very sad. I don't know how he stood it. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, dizziness, trouble breathing. This is not a complete list of possible side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Will plaquenil take joint swelling away Plaquenil for fatigue and pain DailyStrength, What next if plaquenil doesn't work? - Plaquenil side effects dry eyes Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. You should have an eye examination every year to prevent a very rare but serious eye problem. Less than one person in 5,000 develops the problem. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Will you have Joint pain with Plaquenil - eHealthMe. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory pathways. One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. If you miss a dose, take it as soon as you remember. If it is very near the time of the next dose, skip the missed dose and continue with your normal dosing schedule. Do not double dose at one time to catch up. Plaquenil should be stored away from light and moisture and at room temperature up to 86 degrees F.