It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Hydroxychloroquine sulfate 2 Plaquenil and tremors Plaquenil withdrawal headache So there you have it - just one big nasty flare with a new added symptom of heart palpitations. Awesome. I can say that was the worst flare I've ever had - even counting before I started on plaquenil. I guess if you give your immune system an opening that it hasn't had in a while, it's going to go into overdrive. That's the only explanation. If you are taking metoprolol and hydroxychloroquine together, your body may metabolize metoprolol differently than intended. This can cause an increased level of metoprolol in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your dose of metoprolol. In a randomized, double-blind, crossover study, seven healthy subjects with CYP450 2D6 extensive metabolizer phenotypes took 400 mg hydroxychloroquine or placebo twice daily for 8 days, and 100 mg metoprolol orally on the ninth day. Average metoprolol AUC increased by 65% and maximum plasma concentrations increased by 72%. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Can you take plaquenil with metoprolol Other Drugs That Can Interact With Metoprolol Tartrate, Drug Interactions With Metoprolol - Heart Disease Home Page When should plaquenil be thrown out When phenothiazine medications, certain beta blockers, or certain parasite medicines are taken together with Plaquenil, interactions can occur that may affect the drug levels in your blood. This could increase your risk for side effects or decrease the effectiveness of the medicines. Plaquenil Interactions - eMedTV Health Information.. Does plaquenil have a negative effect on metoporol?. Taking Plaquenil for Rheumatoid Arthritis. Metoprolol may impair your thinking or reaction time and affect your ability to drive. Drinking alcohol may enhance these effects. Do not drive if you think your driving ability is being compromised by metoprolol. Metoprolol tartrate. Food can affect absorption. Take tablets with or immediately following food. Metoprolol succinate. Can be taken. WebMD provides information about interactions between Plaquenil Oral and selected-cyp2d6-inhibitors-metoprolol. Avoid taking an antacid or Kaopectate kaolin-pectin within 4 hours before or after you take hydroxychloroquine. Some antacids can make it harder for your body to absorb hydroxychloroquine. What other drugs will affect hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox? Hydroxychloroquine can cause serious liver or heart problems.