Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil and eoe Does hydroxychloroquine always help when taking methotrexate However, dose is usually not more than 800 mg for the first dose and not more than 400 mg for the next doses. Children—Dose is based on body weight and must be determined by your doctor. At first, 13 mg per kg of body weight taken as a single dose. Then, 6.5 mg per kg of body weight taken 6 hours, 24 hours, and 48 hours after the first dose. The guideline is based on actual weight at the time of prescribing, which can maximize dosing and therapeutic effect. “We need more data,” Dr. Rosenbaum said. “We don’t know the lowest effective dose of HCQ, and we don’t know if loading doses are safe. We don’t know if higher doses are safe in patients with higher body weight. There were no differences in hydroxychloroquine levels when both height and ideal body weight were compared across the different blood concentrations. This suggests that we are correctly dosing patients based on actual rather than ideal body weight not exceeding a dose of 400 mg per day and indicated that dosing based on height is unnecessary. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Hydroxychloroquine real weight safe dose Plaquenil Risk Calculators, Great Debate examines questions about hydroxychloroquine. Visual field for plaquenilHow does plaquenil affect your eyesIs plaquenil quinine Chloroquine is often part of a multi-drug regimen with other anti-parasitic medications. A cumulative dose of over 460 g or a daily dose of 2.3 mg/kg body weight/day is high risk. The latest studies show that using the patient's real weight instead of ideal weight correlates better with safe dosing. Chloroquine is rarely an option for rheumatic. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. Hydroxychloroquine Blood Levels in SLE Clarifying dosing.. ACR Actual-weight hydroxychloroquine dosing works in SLE.. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Let's dive in. Melton & Thomas describe the typical safe Plaquenil dosage this way The usual dosage is two 200mg tablets per day. This is generally a "safe" dose for patients having a lean body weight of at least 135 lbs. The generally-regarded safe dosage is 6.5mg/kg/qd, thus the 135 lb. safety threshold. This dose is now considered acceptable, except for individuals of short stature, for whom the dose should be determined on the basis of ideal body weight to avoid overdosage.” 16 The author continues, “The sensitivity and specificity of these tests are not yet known for hydroxychloroquine-related retinal toxicity.